# Cancer Genetics Research Program

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $65,646

## Abstract

ABSTRACT: CANCER GENETICS PROGRAM
The Cancer Genetics (CG) Program of the UNC Lineberger Comprehensive Cancer Center (LCCC) was
established in 2001 to facilitate an integrated, multi-disciplinary approach to genetics research and its
application to clinical care. The program is comprised of laboratory-based investigators, statistical geneticists,
researchers and clinicians, all focused on improving our understanding of cancer etiology and the treatment of
cancer. By integrating the multiple strengths of UNC, ranging from basic science to clinical genomic analysis,
the LCCC Cancer Genetics Program has become a world leader in (i) mechanisms of cancer-associated
genes; (ii) precision oncology and bioinformatics; and (iii) epigenetics/epigenomics. Cancer treatments are
increasingly tailored to an individual’s genomic constitution and the genomic characteristics of the tumor,
mitigating toxicity and enhancing efficacy by precisely targeting mutations that drive tumor propagation. We
have developed a comprehensive program that includes: (i) integrating diverse experimental organisms from
yeast, fly and mouse, to cell-based systems, and ultimately human populations to identify mechanisms that
result in genomic and transcriptomic alterations and the specific lesions responsible for cancer phenotypes; (ii)
use of Whole Genome, Whole Exome and Whole Transcriptome Sequencing (WGS/WES/WTS) as effective
diagnostic tools; (iii) facilitating the meaningful use of genomic information by patients and providers through
structured categorization of genomic variation based on clinical validity and utility; (iv) a state-of-the-art
informatics approach that incorporates generation, analysis, and management of genomic data, coupling
genomic and clinical information to drive both clinical testing and translational research; (v) development of
ethical and practical policies for the use of WGS data by clinicians for patient care; and (vi) exploration of
epigenomic mechanisms and strategies for therapeutic intervention.
Our vision has been realized through value added LCCC resources for the strategic recruitment of faculty in
emerging fields, investment in cutting-edge technology including data handling, enhanced organization for
integrative analyses and the securing of significant federal funding to enable the application of genomics to
diverse aspects of cancer care and prevention. CG consists of 31 members who are associated with 10 basic
science and 3 clinical departments at UNC-Chapel Hill and affiliated institutions. During the last funding period,
program members have published 544 cancer-related articles, 39% were inter-programmatic and 16% were
intra-programmatic (45% collaborative). In 2019, our program members held grants totaling $15.2M (direct
cost) in cancer-relevant extramural funding, including $5.7M (direct costs) from the NCI and $8.6M in other
peer-reviewed funding.

## Key facts

- **NIH application ID:** 10320877
- **Project number:** 5P30CA016086-46
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** TERRY R MAGNUSON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $65,646
- **Award type:** 5
- **Project period:** 1997-06-01 → 2025-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10320877

## Citation

> US National Institutes of Health, RePORTER application 10320877, Cancer Genetics Research Program (5P30CA016086-46). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10320877. Licensed CC0.

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