# Immunogenics and Flow Cytometry

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $314,660

## Abstract

ABSTRACT: IMMUNOGEONOMICS AND FLOW CYTOMETRY SHARED RESOURCE
The Immunogenomics and Flow Cytometry SR (IMCF) is a hybrid core that provides access to state-of-the-art
techniques such as mass cytometry and immunogenomics analysis of bulk and single cell next generation
sequencing data coupled with a high utilization Flow Cytometry facility with a 30-year LCCC history. New
immune monitoring capabilities were developed in response to investigator needs, particularly for the analysis
of immune responses in preclinical tumor models and human clinical research. The immunogenomics
component offers a full suite of immunogenomics techniques, including immune gene signature and pathway
analysis, cell phenotype deconvolution, MHC haplotype prediction, neoantigen prediction, T cell and B cell
repertoire profiling, and systems level analyses such as cytokine network analysis and integrated survival
modeling. This is joined by an investment in CyTOF for expanded panel analysis of cellular phenotypes. This
component currently supports correlative science for tissues being collected from eight immunotherapy trials
and multiple in vivo animal models of cancer. In addition to these new capabilities, the facility also houses a full
complement of highly used analytic flow cytometers and cell sorters for both mouse and human work, New
purchases in addition the CyTOF are two new spectral analytic machines. Most important for the research
community, all SR components have expert staff to support investigators in experimental design, sample
processing, data acquisition, and downstream analysis. IMCF is led by Dr. Vincent, MD, an expert in
immunogenomics and Dr. Fisher, PhD who has led the LCC Flow facility since 2010 and has over 30 years’
experience in flow cytometry. The budget requested ($211,126) is a small proportion of the total operating
budget of $1.7M. Flow cytometry is a traditionally heavily used facility; 80 members were users in fiscal year
2019.

## Key facts

- **NIH application ID:** 10320889
- **Project number:** 5P30CA016086-46
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Benjamin G Vincent
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $314,660
- **Award type:** 5
- **Project period:** 1997-06-01 → 2025-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10320889

## Citation

> US National Institutes of Health, RePORTER application 10320889, Immunogenics and Flow Cytometry (5P30CA016086-46). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10320889. Licensed CC0.

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