# Structural Biology

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $178,027

## Abstract

ABSTRACT: STRUCTURAL BIOLOGY SHARED RESOURCE
The Structural Biology Shared Resource (STRBIO) provides a comprehensive platform of expertise, education,
and infrastructure that enables LCCC researchers to perform cutting-edge structural biological studies. LCCC
members have all the resources needed to determine macromolecular structures using X-ray crystallography,
biomolecular NMR, and single-particle cryo-electron microscopy (cryoEM). This mission is accomplished
through seven complementary components: 1) macromolecular X-ray crystallography, 2) multi-dimensional
nuclear magnetic resonance (NMR) spectroscopy, 3) cryo-electron microscopy, 4) structural bioinformatics, 5)
protein expression and purification, 6) synthesis of peptides and peptidomimetics, and 7) biophysical
measurements of macromolecular properties in solution and their interactions.
Each component of STRBIO is managed by an on-site director with a Ph.D. and years of relevant scientific and
managerial experience. All core directors hold ranks of Assistant Research Professor or higher and most
teach graduate-level classes in their respective disciplines. John Sondek (MT) continues as faculty director of
STRBIO and leads this team of experienced directors. Dr. Sondek has over 20 years of experience in
structural biology and drug discovery and meets bimonthly with core directors as a group to coordinate efforts
and develop strategic plans. The STRBIO was used by 131 users last year. LCCC members accounted for
34% of the use. There are no alternatives to STRBIO on campus or at nearby academic institutions. In fact,
STRBIO attracts numerous users from outside the UNC system due to its competitive rates and extensive
services. STRBIO requests $119,631 for this SR, approximately 6% of the total operating budget of $1.9M.
To accomplish its mission STRBIO will continue to expand services into areas of high demand, areas that take
advantage of the inherent synergies embodied among the STRBIO components, and areas predicted to
provide major advances in cancer biology including new fragment-based drug discovery and expanding
capacity to label proteins isotopically.

## Key facts

- **NIH application ID:** 10320892
- **Project number:** 5P30CA016086-46
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** JOHN E SONDEK
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $178,027
- **Award type:** 5
- **Project period:** 1997-06-01 → 2025-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10320892

## Citation

> US National Institutes of Health, RePORTER application 10320892, Structural Biology (5P30CA016086-46). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10320892. Licensed CC0.

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