# Tissue Procurement Facility & Biospecimen

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $342,848

## Abstract

ABSTRACT: TISSUE PROCUREMENT FACILITY SHARED RESOURCE
The Tissue Procurement Facility (TPF) is the main conduit for access to protocol driven tissue-based research.
As part of the 2019 strategic plan, this SR was expanded and reorganized to provide additional services and
with a more robust pipeline for faculty conducting this type of clinical research. The expansion of this resource
led to enhanced services including:
• More timely fresh tissue collection. TPF has developed a pipeline to collect fresh tissue for next-generation
 research focusing on single-cell and chip sequencing. The fresh tissue infrastructure requires significant
 collaboration between Surgical Pathology, Anatomic Pathology, TPF, and Clinical Protocol and Data
 Management (CPDM). For scRNA sequencing TPF has added an additional workflow to facilitate this
methodology.
• Tissue dissociation. TPF is equipped for single-cell dissociation to process tissue to single-cell for
 investigators that do not have the technology to do so and/or are investigating more robust experiments.
• Ultrapure plasma processing. Ultra highspeed plasma purification for downstream cfDNA analysis.
 Ultrapure plasma will produce a significantly cleaner signal-to-noise ratio for investigators looking at cfDNA.
TPFis led by an experienced faculty and staff. Dr. Calhoun is Director of Surgical Pathology and Anatomical
Pathology at UNC and serves as Pathology Director. He works closely with the surgical liaison, co-leader HJ
Kim to ensure responsible policies are in place for the procurement of research specimens following guidelines
established by the UNC Hospitals. Amy Garratt serves as the Facility Director for the SR and its translational
consenting and collection component. This is a well-managed resource with an operating budget of $1.0M.
TPF requests $229,718 (21% of the total) for fiscal year 2020. LCCC members were more than 66% of the
users in fiscal year 2019, virtually all other users were performing cancer research. The Facility procured, and
distributed 46,091 specimens to support 154 different investigator-initiated studies.

## Key facts

- **NIH application ID:** 10320900
- **Project number:** 5P30CA016086-46
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** HONG JIN KIM
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $342,848
- **Award type:** 5
- **Project period:** 1997-06-01 → 2025-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10320900

## Citation

> US National Institutes of Health, RePORTER application 10320900, Tissue Procurement Facility & Biospecimen (5P30CA016086-46). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10320900. Licensed CC0.

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