# Minimal False-alarm Touch-based Detection of SARS-Cov-2 Virus Particles using Poly-aptamers

> **NIH NIH U01** · GENERAL ELECTRIC GLOBAL RESEARCH CTR · 2022 · $599,859

## Abstract

PROJECT SUMMARY/ABSTRACT
Available tools for detection of SARS-CoV-2 virus require extensive sample preparation and/or expensive lab-
based equipment to obtain accurate results. The objective in this proposal is to build a touch-screen sensor array
to directly capture, detect, and identify model SARS-CoV-2 virus particles with minimal false alarms. This ambi-
tious goal will be achieved by the interdisciplinary team of GE Research scientists and engineers and will be a
synergistic combination of the proposed innovations and the prior scientific and engineering accomplishments
of the team.
 Our proposed solution is based on several innovations driven by eliminating a need for a dedicated sam-
pling step and solving the problems of detection and reliable selective recognition of virus particles, performing
detection/recognition operation in a two-dimensional (2D) format of biosensors, e.g., as a touch-screen surface,
and having this technical solution as a low-profile, low power, unobtrusive device that can be adapted to diverse
application scenarios.
 Innovations of the proposed proof-of-principle touch-screen detector are in three main areas. For virus
recognition, we will create new multifunctional bioreceptors. Our transduction principle will be based on our
earlier reported transduction with the significantly enhanced performance. Our touch surface design will have a
2D array of biosensors.
 The proposed proof-of-principle sensor will be developed in five aims. Aim 1 will focus on demonstration of
new multifunctional bioreceptors. Aim 2 will focus on validation of the functionality of these multifunctional
bioreceptors upon their immobilization on sensor surface. Aim 3 will focus on demonstration of sensing of mod-
el virus particles in a layout of 2D array of biosensors. Aim 4 will focus on demonstration of virus recognition
with immobilized multifunctional bioreceptors in variable ambient conditions. Aim 5 will focus on demonstra-
tion of enhanced detection and recognition of model virus particles in the same layout of 2D array of biosensors
as in Aim 3, but under variable ambient conditions. The findings in this proposed work will change the state-of-
the-art biosensing paradigm and will improve the scientific knowledge, technologies, and workflow practice for
virus detection.

## Key facts

- **NIH application ID:** 10320981
- **Project number:** 4U01AA029324-02
- **Recipient organization:** GENERAL ELECTRIC GLOBAL RESEARCH CTR
- **Principal Investigator:** Radislav A Potyrailo
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $599,859
- **Award type:** 4N
- **Project period:** 2020-12-21 → 2023-05-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10320981

## Citation

> US National Institutes of Health, RePORTER application 10320981, Minimal False-alarm Touch-based Detection of SARS-Cov-2 Virus Particles using Poly-aptamers (4U01AA029324-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10320981. Licensed CC0.

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