# Animal Studies Core

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $158,191

## Abstract

Project Summary/Abstract - Animal Studies Core 
As it has for over a decade, the fee-for-service MDRC Animal Studies Core (ASC) (previously, the Animal 
Phenotyping Core- APC) provides state-of-the art equipment, services, training, and consultation regarding the 
detailed metabolic phenotyping of mouse and rat models of metabolic disease. T 
o address the previously 
unmet needs of MDRC members 
, the MDRC has invested in 
new technology and established a host of new 
services 
over the past five years 
. The ASC will continue to support these technologies and services, providing 
access to crucial equipment, expertise and training to empower specialized studies of rodent models of 
diabetes and related diseases. The ASC consists of four labs: 
1) The Rat Metabolic Phenotyping Lab: includes the assessment of glucose homeostasis, whole animal 
 metabolic assessment, body composition, and other specialized metabolic assessments in rats. 
2) The Optogenetics and Behavioral Phenotyping Lab: provides training and access to optogenetic equipment 
 to examine physiologic and behavioral responses to neural circuit manipulation, as well as with equipment 
 to measure relevant behaviors, such as homeostatic and non-homeostatic feeding, activity, reward, and 
 other behaviors that impact and/or are regulated by metabolic parameters in rodents. 
3) The Continuous Glucose Monitoring Lab: provides continuous assessment of blood glucose concentrations 
 in conscious, unrestrained rodents by radiotelemetry. This technology minimizes the stress of handling 
 rodents and permits a detailed analysis of glucose fluctuations within normal feeding patterns and across 
 extended time-frames. 
4) The Islet Lab: provides islet isolation from mice and rats and ex vivo studies (including perifusion) of islets 
 and other endocrine tissues. 
The ASC directly supports the goals of the MDRC. The services that the ASC provide are unique and are an 
important means to study rodent models of diabetes and related diseases, without which crucial aspects of 
diabetes-related research could not be accomplished. 
This core provides the necessary i 
nfrastructure to 
perform advanced, standardized, metabolic phenotyping of animal models of diabetes and related disorders 
that arise from genetic, pharmacologic, dietary, or other perturbations. The centralized equipment and services 
expedites research for many MDRC investigators in a cost-effective manner and provides access to complex 
metabolic techniques that they may not have otherwise.

## Key facts

- **NIH application ID:** 10321602
- **Project number:** 5P30DK020572-45
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** DARLEEN A. SANDOVAL
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $158,191
- **Award type:** 5
- **Project period:** 1996-12-01 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10321602

## Citation

> US National Institutes of Health, RePORTER application 10321602, Animal Studies Core (5P30DK020572-45). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10321602. Licensed CC0.

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