# Designing Ligand Platforms of Titanium Imido Catalysts and Statistically Screening Alkyne Substrates for [2+2+1] Regioselective Pyrrole Synthesis

> **NIH NIH F32** · UNIVERSITY OF MINNESOTA · 2022 · $42,967

## Abstract

Project Summary/Abstract
 Substituted pyrroles are pivotal organic building blocks in pharmaceuticals, materials, and natural
products, however, these scaffolds are often difficult targets. Recently, a titanium imido complex was
found to be effective in catalyzing [2+2+1] synthesis of pyrroles using simple alkyne and diazene
starting materials. This three-component oxidative coupling offers a new methodology for catalytic
pyrrole synthesis and has the potential to be a valuable synthetic tool for organic synthesis of
pharmaceuticals and natural products containing a pyrrole core. This research proposal seeks to
expand this work by improving regioselective synthesis of pyrroles via catalyst control and to improve
rates of reaction by tuning electronic properties of ancillary ligands by modulating arylchalcogenides.
In addition, dinitrogen will also be utilized as a new nitrogen source for pyrrole synthesis.

## Key facts

- **NIH application ID:** 10322653
- **Project number:** 5F32GM137547-02
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** Daniel N. Huh
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $42,967
- **Award type:** 5
- **Project period:** 2021-01-02 → 2022-07-22

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10322653

## Citation

> US National Institutes of Health, RePORTER application 10322653, Designing Ligand Platforms of Titanium Imido Catalysts and Statistically Screening Alkyne Substrates for [2+2+1] Regioselective Pyrrole Synthesis (5F32GM137547-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10322653. Licensed CC0.

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