# Core B - Technology Core

> **NIH NIH U19** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $262,595

## Abstract

PAN-OMICs TECHNOLOGY CORE 
SUMMARY 
The objective of the Pan-OMICs Technology Core (PTC) is to provide state-of-the-art, innovative -OMICs 
technologies for the targeted and global characterization of Project samples in a quantitative, reproducible, and 
efficient manner. The PTC brings together cutting-edge tools and the expertise of leading systems biologists in 
three critical areas: (1) Genomics led by Dr. Chris Benner at the University of California, San Diego; (2) 
Proteomics led by Dr. Nevan Krogan at the J. David Gladstone Institutes; and (3) Metabolomics led by Drs. 
Ed Dennis and Oswald Quehenberger at the University of California, San Diego (lipidomics) as well as by Dr. 
Leah Shriver at the University of Akron (polar metabolites). The PTC will be responsible for receiving, 
processing, and analyzing both in vivo samples from infected patients and mice (Project 1) as well as ex vivo 
infected samples in culture (Project 2). These data will be integrated by the Modeling Core to identify key 
drivers of influenza virus infection, biomarkers of disease severity, and potential nodes for therapeutic 
intervention. Upon perturbation of these critical drivers by each respective Project, the PTC will provide these 
same services in a comparative manner to determine specific, functional consequences of such perturbations 
for the determination of molecular mechanism. This iterative cycle from systems-to-mechanism is driven by the 
Pan-OMICs Technology Core integrating multiple labs and Projects to optimally leverage best-in-class -OMICs 
approaches to map the molecular pathways surrounding influenza virus infection and disease. 
The PTC has a uniquely challenging and rewarding directive in the generation and integration of coordinated 
systems data spanning chromatin modifications and architecture, gene expression, protein abundance, post- 
translational modifications, protein-protein interactions, lipid profiling, and polar metabolite identification. In the 
previous iteration of our Fluomics consortium, Drs. Benner, Krogan, Dennis, Quehenberger, and Shriver 
worked extensively together to tackle these challenges and derive standardized protocols for sample 
generation, processing, and analysis between different cores and institutes. Formalizing this relationship as a 
single core under the leadership of Dr. Nevan Krogan, an internationally recognized expert in the design and 
application of systems biology approaches to interrogate host-pathogen interactions, the PTC is ideally 
positioned to both effectively and efficiently implement these previously developed pipelines for the 
accomplishment of our Aims.

## Key facts

- **NIH application ID:** 10322683
- **Project number:** 5U19AI135972-05
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Nevan Krogan
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $262,595
- **Award type:** 5
- **Project period:** 2018-01-20 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10322683

## Citation

> US National Institutes of Health, RePORTER application 10322683, Core B - Technology Core (5U19AI135972-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10322683. Licensed CC0.

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