# Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older Latinos

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 2022 · $839,568

## Abstract

Latinos are the fastest growing subpopulation of older adults in the U.S.A. and have a greater prevalence of
Alzheimer’s disease (AD) than non-Latino whites (1). Despite this, our knowledge of normal aging, cognitive
decline, and AD-related neurodegeneration in Latinos is sparse. A growing body of evidence supports a link
between AD onset and several modifiable factors, some of which convey risk (e.g., mid-life hypertension, sleep
and mood distrurbance). Other factors are considered protective, such as engaging in regular physical activity,
managing cardiovascular risk factors (i.e., diabetes, obesityand hypertension), maintaining a healthy diet, and
engaging in lifelong learning (2). It is also known that some of these modifiable risk factors have a higher
prevalence in Latinos, compared to non-Latinos (3). Nonetheless, how these factors independently or
interactively make older Latinos more vulnerable to accumulation of AD pathology, cognitive decline, and
dementia remains unclear. Thus, investigating the impact of different AD risk factors on cognition, brain
function, and AD molecular markers of pathology in older Latinos is pivotal to improving prevention,
early detection, and development of novel treatments and interventions for this critically underserved
and understudied population.
 To promote recruitment and participation of Latinos in biomarker and aging research, we initiated a registry
of older community-dwelling Latinos living in Massachusetts (known as the Boston Latino Aging Registry).
Furthermore, with the support of an administrative supplement in 2019 we began to include more Latino
participants in the ongoing NIA-funded Harvard Aging Brain Study, which is now known as Latino HABS. We
propose to build upon these previous recruitment efforts to study aging and preclinical AD in non-demented
older Latinos and non-Latino White individuals. All participants will undergo a comprehensive assessment of
cognition, amyloid and tau PET scanning, as well as structural and resting fMRI. They will also complete self-
report measures of modifiable dementia risk factors (e.g. cardiovascular disease, sleep, mood), all of which will
be used to create an overall dementia risk score. Comparisons between Latinos and non-Latinos will be made
in all aims with the goal of using the findings to validate and inform biomarker findings in older Latinos.
 Our ultimate goal is to build a cohort of older Latinos that we can be followed up overtime. For the current
R01 grant, we propose to enroll a total of 200 older community dwelling individuals (60-80 years; 150 Latinos
and 50 non-Latinos) and compare them to 200 already enrolled in HABS (60-80 years; 150 non-Latinos and 50
Latinos) to 1) investigate modifiable dementia risk factors and cognition in older Latinos and non-Latinos; 2)
examine modifiable dementia risk factors and memory network dysfunction in older Latinos and non-Latinos;
and 3) examine the associations between modifiable dementia risk fact...

## Key facts

- **NIH application ID:** 10322722
- **Project number:** 5R01AG066823-02
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Yakeel T. Quiroz
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $839,568
- **Award type:** 5
- **Project period:** 2021-01-01 → 2025-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10322722

## Citation

> US National Institutes of Health, RePORTER application 10322722, Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older Latinos (5R01AG066823-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10322722. Licensed CC0.

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