Project Summary Bioinformatics Facility, supported by the Cancer Center Support Grant (CCSG) awarded to the Wistar Institute, collaborates with the vast majority of cancer center members on multiple research projects. My role as a Scientific Director of the Bioinformatics Facility is to be engaged on all steps of many of those research programs. The institute-wide involvement in cancer-related studies allows me to develop comprehensive data analyses pipelines applicable across multiple programs, as well as to re-use result elements, including databases, summarized and annotated datasets and other integrative resources, in analyses customized to particular studies. In combination with project-specific research efforts, which in turn contribute to the existing knowledgebase, the integrative approach provides a robust scientific environment for applying methods of computational biology to various cancer-related studies as demonstrated in the application.