# Cancer genes: translating basics to applications

> **NIH NIH R35** · SCRIPPS RESEARCH INSTITUTE, THE · 2022 · $1,082,187

## Abstract

   
DESCRIPTION (provided by applicant): The proposal focuses on molecular mechanisms of oncogenesis. It includes three major projects. The first deals with lncRNAs (long non-coding RNAs) that are specifically regulated by the oncoprotein MYC and by the oncogenic H1047R mutant of p110a of PI3K (phosphatidylinositol 3-kinase). The second focuses on the application of a novel and quantitative proteomic technique, QBID, to determine stimulus-specific changes in the interactomes in the PI3K pathway. The third project consists of a structural analysis of the
p110-p85 complex of PI3K. Each of these projects is highly and directly cancer-relevant. Progress on these fronts will have an impact on the translation of basic knowledge into clinical medicine.

## Key facts

- **NIH application ID:** 10322977
- **Project number:** 5R35CA197582-07
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** PETER K VOGT
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,082,187
- **Award type:** 5
- **Project period:** 2016-01-08 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10322977

## Citation

> US National Institutes of Health, RePORTER application 10322977, Cancer genes: translating basics to applications (5R35CA197582-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10322977. Licensed CC0.

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