# MMP-12 as an Endogenous Post-MI Resolution Promoting Factor

> **NIH NIH R01** · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2022 · $381,250

## Abstract

Abstract
 About one in four myocardial infarction (MI) patients progress to develop congestive heart failure, which
has a 5-year mortality rate of 50%. The goal of this project is to understand post-MI roles of matrix
metalloproteinase-12 (MMP-12) by establishing how MMP-12 serves as a resolution promoting factor to
stimulate the transition from inflammation to repair. We hypothesize that MMP-12 regulates individual
neutrophil, macrophage, and fibroblast physiology to promote the resolution of post-MI inflammation
and stimulate repair. Our specific aims will explore the mechanism whereby MMP-12 turns off pro-
inflammation (aim 1), initiates anti-inflammation (aim 2), and promotes repair (aim 3). Innovation lies in the
evaluation of MMP-12 post-MI to connect early cell functions to late remodeling outcomes and in the
integration of multi-discipline approaches to explore the mechanisms whereby MMP-12 regulates resolution.
This study will drive forward the understanding of the molecular basis of LV remodeling and will identify novel
intervention targets directed at MMP-12.

## Key facts

- **NIH application ID:** 10327670
- **Project number:** 5R01HL137319-04
- **Recipient organization:** UNIVERSITY OF NEBRASKA MEDICAL CENTER
- **Principal Investigator:** MERRY L. LINDSEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $381,250
- **Award type:** 5
- **Project period:** 2019-02-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10327670

## Citation

> US National Institutes of Health, RePORTER application 10327670, MMP-12 as an Endogenous Post-MI Resolution Promoting Factor (5R01HL137319-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10327670. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*