SUMMARY The goal of the Harvard-wide Program on Antibiotic Resistance is to apply innovative advanced technologies to developing new strategies for treating leading causes of multidrug resistant hospital-associated infection caused by staphylococci and enterococci. This multi-investigator project brings together experts from fields ranging from mathematics and systems biology to infectious disease clinicians, and the Administrative Core creates an infrastructure for them to work collaboratively and synergistically, bringing new insights and capabilities to bear in solving the leading public health crisis of antibiotic resistant infection. The Administrative Core functions as a central resource for facilitating interaction among Subproject and Core Investigators, to ensure program synergy, executing and tracking subcontract expenditures to ensure efficient project performance, recording and compiling records to track and manage progress, connecting the Program Project to other initiatives to leverage its resources, and for ensuring the timely reporting of results and financial status to NIAID Program staff. The Administrative Core will continue to strive to foster the existing synergy in attainment of project goals and milestones. To do this, the Administrative Core will provide program management and oversight, facilitate interactions between participants, provide critical infrastructure for fiscal management of the program, provide connectivity to and leverage from other Harvard-wide initiatives, including the Microbial Sciences Initiative (MSI) and Catalyst Clinical and Translational Sciences Center, and provide a single point of contact and active coordination for on-going communication with NIAID and the Program Officer, and other NIAID initiatives, including data sharing. As a result of internal and external synergies, the impact of the Harvard-wide Program on Antibiotic Resistance is much greater than would otherwise be possible through individual research efforts.