# Humanized Mouse Core

> **NIH NIH P01** · OREGON HEALTH & SCIENCE UNIVERSITY · 2022 · $302,228

## Abstract

SUMMARY - HUMANIZED MOUSE CORE (CORE A)
The huNSG mouse model nicely recapitulates aspects of human biology that are not supported in other
systems. This humanized mouse model also offers the only small animal model capable of supporting HCMV
infection, latency, and reactivation. This PPG requires our highly standardized huNSG model in order to
effectively characterize unique conditions and quantitatively differentiate viral growth and dissemination of
different viral mutants and treatments. Core A will provide the infrastructure and knowledge required for
completion of the proposed research projects involving huNSG mice and standardize analysis between all
projects to allow for direct comparisons. By working directly with the Project leaders, Core A will aid in
designing and execution of the proposed experiments.

## Key facts

- **NIH application ID:** 10327946
- **Project number:** 2P01AI127335-06
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Patrizia Caposio
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $302,228
- **Award type:** 2
- **Project period:** 2017-08-15 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10327946

## Citation

> US National Institutes of Health, RePORTER application 10327946, Humanized Mouse Core (2P01AI127335-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10327946. Licensed CC0.

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