# Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites

> **NIH NIH P01** · WISTAR INSTITUTE · 2022 · $1,244,471

## Abstract

Project Summary
The first project of our pan-CoV proposal is titled ‘Development of broad nanovaccines targeting diverse
coronavirus receptor-binding sites’. Our team’s expertise will culminate in structurally guided coronavirus
nanoparticle vaccines to broaden CoV vaccine protection. This proposal utilizes our novel platform to
develop potent, RBS-focused nanoparticle vaccines to induce broad protection across CoV lineages,
escape mutations and potential pandemic CoVs that are of concern. The project aims are: (1) Create a
library of mutants that escape coronavirus immunity (2) Develop RBS-focused nanoparticle vaccines to induce
broadly neutralizing antibodies to conserved sites using nucleic acid delivery and (3) Develop vaccine regimens
to induce broad immunity and protection across diverse CoVs.

## Key facts

- **NIH application ID:** 10328140
- **Project number:** 1P01AI165066-01
- **Recipient organization:** WISTAR INSTITUTE
- **Principal Investigator:** Daniel Kulp
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,244,471
- **Award type:** 1
- **Project period:** 2022-09-22 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10328140

## Citation

> US National Institutes of Health, RePORTER application 10328140, Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites (1P01AI165066-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10328140. Licensed CC0.

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