# Mouse and Human Liver Surgery Core

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $271,605

## Abstract

Core B – Summary
Core B of Human and Mouse Liver Surgery will be responsible for patient consent, human sample collection
and screening, as well as conducting microsurgery procedures related to mouse models of hepatic IRI and
OLT for all three projects in this PPG. The specific aims are as follows: Aim 1. To collect, process, and store
human biological samples from OLT patients. Donor liver biopsy tissue and peri-, intra- and post-operative
blood and fluid samples from the operative field and blood samples peripherally will be collected. Processing
and storage will be centralized. Analysis by request from individual projects will be performed. Core B will also
collect and maintain the database with all relevant patient data for the PPG duration. Aim 2. To provide OLT
and local liver IRI murine microsurgeries and post-operative care in mice with quality and consistency.
The Core will be responsible for conducting all the microsurgical OLT/non-transplant procedures and post-
transplant care in mice in all three projects. These procedures are technically demanding, and the Core will
assure consistent and reliable surgical outcomes in conducting experiments, as proposed in this PPG. Aim 3.
To coordinate experiments among projects and maximize the use of biological samples from human
OLT patients and mouse liver transplants/recipients. The Core will coordinate experiments between
projects to i/ maximize the use of clinical samples from transplanted patients, and ii/ minimize the numbers and
costs of experimental animals for microsurgeries. Aim 4. To store extra-human/mouse biological samples
and maintain the archive. The Core will store and record surplus tissue samples (liver grafts, host tissues,
serum) and maintain them as an archive for potential future use. Aim 5. To offer other surgical support.
Based on the experience, and available equipment, Core B will provide support for additional surgical
procedures in mouse liver IRI models, such as i.v., and portal vein injections. Core B will enable collaborating
PIs of all three projects to achieve their goals by providing skilled technical and scientific expertise and
guidance in the key areas of human and liver transplantation surgery, critical to the successful performance of
the PPG.

## Key facts

- **NIH application ID:** 10328211
- **Project number:** 2P01AI120944-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Fady M Kaldas
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $271,605
- **Award type:** 2
- **Project period:** 2017-08-01 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10328211

## Citation

> US National Institutes of Health, RePORTER application 10328211, Mouse and Human Liver Surgery Core (2P01AI120944-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10328211. Licensed CC0.

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