# SUPPORT FOR HPV16L1/RG1 CHIMERIC VIRUS-LIKE PARTICLE VACCINE CLINICAL DEVELOPMENT TASKS 1&2

> **NIH NIH N01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2021 · $28,823

## Abstract

Background: Currently marketed HPV vaccines protect against infection by virus types associated with up to 90% of cervical/mucosal cancers (Guardasil 9).  To potentially expand protection to all HPV types, Drs. Richard Roden, of Johns Hopkins University, and Reinhard Kirnbauer, of the Medical University of Vienna, have designed a chimeric HP16 L1 virus like particle that displays a highly conserved, immunogenic epitope of L2 on the surface of the VLP. Preclinical studies support the effectiveness of this vaccine against a large number of HPV types.  The NCI PREVENT Cancer Preclinical Drug Development Program is currently producing clinical grade HPV16L1/RG1 chimeric VLP vaccine for non-clinical safety and Phase I and Phase II, proof of concept testing.  The product will be adjuvanted with alum/MPL and thus very similar to Cervarix.  While the details of the clinical testing plan are still under development, it is anticipated that the Phase I testing will involve three vaccinations (at 0, 2 and 6 months) with dose-escalation through three dose-levels (20, 40, and 80 µg).

## Key facts

- **NIH application ID:** 10329653
- **Project number:** 261201500026I-P00010-26100002-1
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **Principal Investigator:** ALEXANDER LYUBIMOV
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $28,823
- **Award type:** —
- **Project period:** 2015-09-25 → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10329653

## Citation

> US National Institutes of Health, RePORTER application 10329653, SUPPORT FOR HPV16L1/RG1 CHIMERIC VIRUS-LIKE PARTICLE VACCINE CLINICAL DEVELOPMENT TASKS 1&2 (261201500026I-P00010-26100002-1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10329653. Licensed CC0.

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