# NCI-DCEG;  Automated evaluation of biomarker-stained slides;

> **NIH NIH N01** · LEIDOS BIOMEDICAL RESEARCH, INC. · 2021 · $434,049

## Abstract

Cervical cancer screening is shifting from Pap cytology to primary HPV testing. While HPV testing provides greater reassurance for HPV-negative women, additional tests are needed for HPV-positive women to decide who needs further diagnostic evaluation or treatment. We have developed a novel HPV triage strategy based on automated evaluation of cervical cytology slides stained with p16 and Ki-67 (dual stain). In the initial evaluation, this approach has shown improved accuracy compared to Pap testing and manual dual stain. Now, we are evaluating the approach in a large population of HPV-positive women enrolled in the IRIS cohort.

## Key facts

- **NIH application ID:** 10329713
- **Project number:** 261201500003I-P00002-26100070-1
- **Recipient organization:** LEIDOS BIOMEDICAL RESEARCH, INC.
- **Principal Investigator:** MARY OLANICH
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $434,049
- **Award type:** —
- **Project period:** 2018-09-24 → 2023-09-23

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10329713

## Citation

> US National Institutes of Health, RePORTER application 10329713, NCI-DCEG;  Automated evaluation of biomarker-stained slides; (261201500003I-P00002-26100070-1). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/10329713. Licensed CC0.

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