# Molecular Basis of Allergic and Immunologic Disease

> **NIH NIH T32** · BOSTON CHILDREN'S HOSPITAL · 2022 · $692,230

## Abstract

The prevalence of pediatric allergic, immunological and rheumatologic disorders has been steadily increasing
with more than 15% of children now affected. However, the number of physicians trained to treat children with
these conditions as well as to investigate the genetics, pathogenesis and innovative approaches to therapy of
these disorders remains disproportionately small. In addition, the role of the immune response in modulating
the clinical course of infectious disease is coming into sharp focus with the COVID-19 pandemic. There is a
great need both to advance understanding of the basic immunobiology underlying these conditions and to
generate a highly qualified workforce of investigators who will do this work. Recent advances in understanding
of the immune system, along with the emergence of powerful yet complex research technologies in molecular
biology, transcriptomics, metabolomics, human genetics, epigenetics, structural biology, cell biology and
immunology have not only created fertile ground for advancement of understanding of immunological
mechanisms but have made it essential for trainees to develop understanding of and experience in these
approaches. Such training will prepare MD and PhD scientists to advance our knowledge through basic
research, clinical investigation and the implementation of novel therapeutic strategies. Equally important, it will
generate a cadre of physician scientists ready to train the next generation of investigators. The proposed
training program will recruit a diverse group of the most talented and committed young pediatric physician
scientists as well as PhD’s (all postdoctoral) committed to clinically relevant immunology research and will
provide them with an intensive training experience in research in an unparalleled environment. In the year prior
to enrollment in the program, physicians will receive one year of clinical training (not funded by this grant). All
training will be within the general discipline of Immunology, with a broad representation of immunological
disorders (including asthma, food allergy, atopic dermatitis, primary immune deficiency syndromes, systemic
lupus erythematosus, Kawasaki disease) and basic immunological mechanisms (such as tolerance,
immunogenomics, epigenetics, innate immunity, cellular immunology and immune responses to SARS-CoV-2)
covered by an internationally recognized faculty in the Harvard Medical School community. A three-year
training experience is proposed for 9 trainees per year, each with MD, MD-PhD or PhD credentials.

## Key facts

- **NIH application ID:** 10330698
- **Project number:** 2T32AI007512-36
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **Principal Investigator:** RAIF SALIM GEHA
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $692,230
- **Award type:** 2
- **Project period:** 1986-08-01 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10330698

## Citation

> US National Institutes of Health, RePORTER application 10330698, Molecular Basis of Allergic and Immunologic Disease (2T32AI007512-36). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10330698. Licensed CC0.

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