# Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner

> **NIH NIH R35** · RESEARCH INST OF FOX CHASE CAN CTR · 2022 · $481,525

## Abstract

PROJECT SUMMARY/ABSTRACT
 My laboratory is interested in understanding the molecular mechanisms underlying cell adhesion and
motility mediated by integrins and related small GTPases, and applying these findings to the development of
new class of inhibitors for potential therapeutic benefits. Integrins are cell adhesion molecules that transduce
signals across the plasma membrane in both directions. Thrombotic disorders, cardiovascular diseases, T cell
proliferation defects, and many autoimmune diseases have been linked to the misregulation of integrin
expression and its activity. The major gaps in the field of integrin and related signaling pathways include
inaccurate molecular models of signaling events mediated by the integrin activator, a lack of understanding to
the regulation of different integrin species, unknown mechanism underlying the peculiar dual GTPase specificity
of their effector protein, and a lack of inhibitors targeting intracellular adaptors.
 We have obtained substantial preliminary data to bridge this gaps. The main goals of the lab for the next
five years are to investigate the signaling mechanisms of the adaptors and integrins, focusing on the connection
of isoforms and posttranslational modifications with specific integrin species and related GTPases, and to
develop a new class of adaptor protein inhibitors to control integrin functions. The proposed studies include both
basic research and translational research, which reflect an ever-expanding scope of the research in our research
program. Our vigorous efforts would undoubtedly support us to achieve the overall goal of conquering integrin
related diseases by more effective therapeutic interventions.

## Key facts

- **NIH application ID:** 10330819
- **Project number:** 2R35GM119560-06
- **Recipient organization:** RESEARCH INST OF FOX CHASE CAN CTR
- **Principal Investigator:** Jinhua Wu
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $481,525
- **Award type:** 2
- **Project period:** 2016-09-01 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10330819

## Citation

> US National Institutes of Health, RePORTER application 10330819, Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner (2R35GM119560-06). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10330819. Licensed CC0.

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