# Regulation of spore peptidoglycan modification

> **NIH NIH R01** · TUFTS UNIVERSITY BOSTON · 2022 · $323,720

## Abstract

SUMMARY
The bacterial pathogen, Clostridioides difficile, has been designated an urgent threat to the US healthcare
system by the Centers for Disease Control. In order for C. difficile to initiate infection, its infectious spore form
must germinate in the gut of susceptible individuals. Since spore germination depends on the spore cell wall
undergoing specific modifications, determining how this process occurs in C. difficile could inform the
development of strategies for preventing C. difficile disease transmission and recurrence.

## Key facts

- **NIH application ID:** 10331314
- **Project number:** 5R01GM140361-02
- **Recipient organization:** TUFTS UNIVERSITY BOSTON
- **Principal Investigator:** Aimee Shen
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $323,720
- **Award type:** 5
- **Project period:** 2021-02-01 → 2024-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10331314

## Citation

> US National Institutes of Health, RePORTER application 10331314, Regulation of spore peptidoglycan modification (5R01GM140361-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10331314. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*