# The Impact of Maternal CMV Infection on Birth Outcomes

> **NIH NIH R03** · MICROGEN, LLC · 2022 · $89,515

## Abstract

Congenital Cytomegalovirus (CMV) infection is a leading cause of birth defects and developmental disabilities in the U.S., affecting thousands of children each year. Notably, the majority of children acquire congenital CMV from non-primary maternal CMV infection rather than primary infection. Thus, determining the maternal serostatus in the field may further our understanding of the association between CMV infection status and worse pregnancy outcome, and risk stratify pregnant women during gestation. Current methods to detect maternal CMV serostatus are labor intensive and require sophisticated equipment, dedicated laboratory space, and trained technicians. We propose developing a point-of-care (POC) test for rapid screening of maternal CMV serostatus. A rapid, on-site test for CMV serostatus screening in biospecimens would: (1) allow for immediate counseling and confirmatory testing, and (2) avoid having to create new laboratory infrastructure for biospecimen testing. Alternatively, a rapid POC test that could be utilized during initial study screening visits would permit the efficient identification and enrollment for CMV vaccine testing.

## Key facts

- **NIH application ID:** 10331331
- **Project number:** 5R03AI151426-02
- **Recipient organization:** MICROGEN, LLC
- **Principal Investigator:** Raymond Preston Stowe
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $89,515
- **Award type:** 5
- **Project period:** 2021-01-22 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10331331

## Citation

> US National Institutes of Health, RePORTER application 10331331, The Impact of Maternal CMV Infection on Birth Outcomes (5R03AI151426-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10331331. Licensed CC0.

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