# Core B (Animal Core)

> **NIH NIH P01** · MICHIGAN STATE UNIVERSITY · 2022 · $588,058

## Abstract

Project Summary – Core B
Core B (Animal Core) serves as a central resource for all animals used by all investigators in the Program Project.
Core personnel are responsible for maintaining up-to-date assessments of animal requirements for all Projects.
They ensure timely ordering, delivery, and proper husbandry of animals. All animal surgery is conducted and/or
supervised by Core B personnel. This includes production of mid-thoracic aorta coarctation rats and mice,
thymectomized rats, and appropriate sham-operated controls, most routine tissue removal and preservation for
in vitro analysis, and instrumentation of rats for chronic hemodynamic monitoring. Most animals used in the
Program Project have their blood pressure carefully and reliably quantified by Core B personnel either directly
(radiotelemetry transmitter) or indirectly (systolic pressure by tail-cuff sphygmomanometry) as part of each
experimental protocol. Daily animal husbandry, health surveillance and record keeping also are the responsibility
of Core B personnel, in association with the staff of Campus Animals Resources (CAR) of Michigan State
University. Core B personnel also are responsible for implementing new physiological techniques for evaluating
cardiovascular function and developing new transgenic animal models that support the goals of the Program
Project. A major advantage of Core B is that it facilitates the most efficient use of animals by Program
Investigators. Our in vivo protocols also are designed to maximize the amount of data collected from a single
animal. This is achieved through use of long-term repeated measurements of cardiovascular parameters where
possible, rather than studying separate groups of rats at each time point of interest. At the end of chronic in vivo
protocols, tissue samples from the animals are distributed to one or more Program investigators for further study.

## Key facts

- **NIH application ID:** 10331575
- **Project number:** 1P01HL152951-01A1
- **Recipient organization:** MICHIGAN STATE UNIVERSITY
- **Principal Investigator:** Dale Adam Lauver
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $588,058
- **Award type:** 1
- **Project period:** 2021-12-22 → 2026-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10331575

## Citation

> US National Institutes of Health, RePORTER application 10331575, Core B (Animal Core) (1P01HL152951-01A1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10331575. Licensed CC0.

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