# BTRF - SR Compnent

> **NIH NIH P30** · UNIVERSITY OF VIRGINIA · 2022 · $100,149

## Abstract

BIOREPOSITORY AND TISSUE RESEARCH FACILITY (BTRF) – PROJECT SUMMARY
 The Biorepository and Tissue Research Facility (BTRF) makes human biospecimens available for basic,
translational, and clinical research. It is the major conduit through which human tissue specimens are
transferred from the Pathology, Surgery, and other clinical departments to research labs at the University of
Virginia Cancer Center (UVACC) and is the major processor of human biofluids (blood, urine, etc.) in support
of clinical trials at the UVACC. The biorepository functions are supported by a robust informatics platform that
is integrated with other clinical and research informatics resources. In addition, this facility provides standard
histology services and complex histology-based analytic techniques for animal models of cancer as well as
human tissues, including tissue microarray construction, laser microdissection, immunohistochemistry
(including multi-color chromogens), RNA in situ hybridization, and digital slide scanning with automated image
analysis. The BTRF provides expert histopathology support from Board-certified Anatomic Pathologists. The
biorepository and analytic services are often vertically integrated with each other, including procedures in other
Shared Resources, to allow for “one-stop shopping” for investigators carrying out translational or clinical cancer
research. Examples include next generation sequencing or RNA microarray analysis carried out in the
Biomolecular Analysis Facility from nucleic acids extracted from tissue samples by the BTRF; and circulating
tumor cell analysis carried out in the Flow Cytometry Core from blood samples processed in the BTRF. BTRF
services enable new insights into cancer disease mechanisms via the analysis of tissues and biofluids, assist
in the discovery and validation of new clinical cancer biomarkers, and support clinical trials of therapies for
cancer.

## Key facts

- **NIH application ID:** 10332959
- **Project number:** 2P30CA044579-31
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** Craig Andrew Rumpel
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $100,149
- **Award type:** 2
- **Project period:** 1997-09-16 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10332959

## Citation

> US National Institutes of Health, RePORTER application 10332959, BTRF - SR Compnent (2P30CA044579-31). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10332959. Licensed CC0.

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