# Senescence dysregulates of inflammation-resolution programs in atherosclerosis

> **NIH NIH R01** · ALBANY MEDICAL COLLEGE · 2021 · $48,357

## Abstract

Project abstract
Atherosclerotic cardiovascular disease (CVD) is the leading cause of death in the industrialized world. Failed
resolution of a chronic inflammatory response is an important driving force in the progression of atherosclerosis.
Resolution is mediated by the critical balance between specialized pro-resolving mediators (SPMs) such as
lipoxins and resolvins and pro-inflammatory factors like leukotrienes (LTs) and prostaglandins (PGs).
work
SPMs
processes plaques and b) mechanisms associated with the protective
actions of SPMs in atherosclerosis. Therefore, the overall objective of this administrative supplement is for
Masharh Lipscomb to understand new mechanisms of dysregulated resolution in atherosclerosis and to
harness new SPM signaling pathways towards a novel treatment strategy. Cellular senescence is an
irreversible cell cycle arrest that leads to a highly pro-inflammatory phenotype called the senescence-
Previous
from our lab and others suggest that SPMs are defectively synthesized in plaques and that restoration of
prevents atherosclerosis progression in mice. Gaps remain in our understanding as to a) what cellular
derange the synthesis of SPMs in
associated secretory phenotype (SASP). We and other observed that senescent cells accumulate in
atherosclerosis
cleared
and a major goal of Masharh work is to uncover why these harmful cells cannot be readily
and neutralized.We postulate that the SASP drives an increase in key “don't' eat me” signals that coax
macrophages to limit clearance. This administrative supplement will allow Masharh Lipscomb to learn new
techniques while also increasing the quality of the deliverables on the parent grant.

## Key facts

- **NIH application ID:** 10333044
- **Project number:** 3R01HL153019-02S1
- **Recipient organization:** ALBANY MEDICAL COLLEGE
- **Principal Investigator:** Gabrielle Fredman
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $48,357
- **Award type:** 3
- **Project period:** 2020-07-15 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10333044

## Citation

> US National Institutes of Health, RePORTER application 10333044, Senescence dysregulates of inflammation-resolution programs in atherosclerosis (3R01HL153019-02S1). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10333044. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*