PROJECT SUMMARY – BIOSPECIMEN SERVICES SHARED RESOURCE (BSSR) The mission of the BSSR is to support innovative translational research to advance the prevention, diagnosis, and treatment of cancer through the provision of biospecimens and clinical data. The Specific Aims are to: 1) collect data and specimens from OSUCCC cancer patients using the IRB-approved Total Cancer Care (TCC) universal consenting and biobanking protocol for future unspecified research; 2) prospectively procure biospecimens for specific IRB-approved protocols; and 3) provide high quality, centralized biorepository services for IRB-approved, grant-funded and large institutional projects in a CAP-accredited biorepository. Over the current grant cycle, the major changes for the BSSR include: a) implementation of TCC across all Disease Specific Research Groups (DSRGs) covering all cancers - TCC now includes 57,256 consented subjects resulting in regular usage of biospecimens and data; and, b) the ORIEN AVATAR program was initiated, providing OSUCCC members with research grade next generation exome sequencing results on tumor and normal tissue with clinical annotation from 3,049 TCC subjects at OSU and 11,500 across ORIEN (the OSUCCC is a major contributor of samples). During the current grant cycle, the BSSR provided key services in support of 122 publications (35 > 10 impact factor), 105 users, and 24 NCI grants, including 1 K01, 1 K12, 2 P01s, 2 P50s, 11 R01s, 4 R21s, 1 U10, 1 UH2, and 1 UM1. Over the next grant cycle, BSSR will contribute to each of the new strategic priorities for the OSUCCC by providing biospecimens and high quality genomic and clinical data as requested by immuno-oncology, translational genomics, cancer engineering and cancer prevention and survivorship investigators. Each area will be supported by the TCC, and given the robust faculty recruitment and regularly increasing patient volumes; there will be an increase in prospective procurement and biobanking as well. Given the robust OSUCCC recruitment and increasing patient volumes, demand for services and new technologies will increase. The BBSR will expand its staff, instrumentation and services before capacity is reached. The annual budget of the BSSR is $2,206,277, yet the CCSG request is $179,168. As such, The BSSR leverages extensive institutional support and seeks only 8.1% support from CCSG funds.