# Core B - Retrotransposon Genomics, Technology and Analysis Core

> **NIH NIH P01** · BROWN UNIVERSITY · 2022 · $506,770

## Abstract

Core Summary
Core B will provide cutting edge tools to measure retrotransposition in
multicellular eukaryotes in the context of aging paradigms with a special focus on
Alzheimer’s disease and related disorders. In addition to providing appropriate
existing assays and mouse models to all of the participants, the core will also
develop improved retrotransposition reporters and genomics tools to enable the
detection and mapping of retrotransposition events in the various experimental
systems under study. The Core will also provide “Driver systems” that lead to
high level expression of these elements in both cell systems and animals. Finally,
the core will provide cutting edge sequencing and computational tools to analyze
both retrotransposition itself and the aberrant forms of LINE-1 expression and
reverse transcription observed in aging cells and organisms.

## Key facts

- **NIH application ID:** 10333659
- **Project number:** 2P01AG051449-06
- **Recipient organization:** BROWN UNIVERSITY
- **Principal Investigator:** Jef D BOEKE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $506,770
- **Award type:** 2
- **Project period:** 2016-09-01 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10333659

## Citation

> US National Institutes of Health, RePORTER application 10333659, Core B - Retrotransposon Genomics, Technology and Analysis Core (2P01AG051449-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10333659. Licensed CC0.

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