# Administrative supplement to K01MH110647 that was significantly impacted by the COVID-19 pandemic

> **NIH NIH K01** · HOWARD UNIVERSITY · 2021 · $53,136

## Abstract

PROJECT SUMMARY
The goal of this supplement award is to provide supplemental supports to cover the time and
effort the applicant is needed to complete the aims of the parent award (K01MH110647) which
was significantly impacted by COVID-19 mitigation efforts. The specific aims that have been
pursued during the parent award period are: Aim 1) to examine effects of pharmacologically
blocking the orexin system after written narrative exposure (WNE) on sleep, posttraumatic
stress disorder (PTSD) symptoms, and intersession habituation; and Aim 2) to use an animal
model to elucidate neural mechanisms underlying the effects of inhibiting the orexin system on
sleep and memory consolidation following fear extinction. To accomplish Aim 1, the applicant
has been conducting a clinical trial in which adult participants with PTSD complete WNE in the
evening and morning with intervening sleep, and either suvorexant (a dual orexin receptor
antagonist, an FDA-approved drug for treating insomnia) or placebo are administered prior to
going to bed following the evening WNE. To accomplish Aim 2, the applicant has been
conducting mouse experiments in which orexin neurons in the hypothalamus are inhibited using
optogenetic methods following a fear extinction training. For the career development activity, the
applicant has been receiving in-lab training to learn advanced animal study methodologies,
including optogenetics and telemetric sleep recording. Both clinical and animal studies and
career development activities have been significantly delayed due to COVID-19 mitigation
efforts. During the proposed supplement award period, the applicant will continue and complete
the research and training activities within the scope of the parent grant aims.

## Key facts

- **NIH application ID:** 10333982
- **Project number:** 3K01MH110647-04S1
- **Recipient organization:** HOWARD UNIVERSITY
- **Principal Investigator:** Ihori Kobayashi
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $53,136
- **Award type:** 3
- **Project period:** 2017-04-04 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10333982

## Citation

> US National Institutes of Health, RePORTER application 10333982, Administrative supplement to K01MH110647 that was significantly impacted by the COVID-19 pandemic (3K01MH110647-04S1). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10333982. Licensed CC0.

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