COMMUNITY OUTREACH & ENGAGEMENT PROJECT SUMMARY/ABSTRACT The UC Irvine (UCI) Chao Family Comprehensive Cancer Center (CFCCC) Catchment Area is Orange County (OC) which represents Region 10 of the California Cancer Registry and in which 70% of CFCCC cancer patients reside. OC is the third most populous county in California and the sixth most populous county in the U.S. Nearly two-thirds of county residents are from ethnically-diverse populations and 30% are foreign-born who speak a total of more than 35 different languages at home. Poverty is higher in these OC populations, as 17% of Latinos, 13% of Vietnamese, 13% of African Americans, 13% of Koreans and 10% of Chinese have incomes below the federal poverty line, compared to only 5% of non-Hispanic Whites. Geographically, the majority of these diverse populations reside in central and north parts of OC. UCI is designated by the U.S. Department of Education as both a Hispanic-Serving Institution and an Asian American/Native American Pacific Islander-Serving Institution, and we are the sole NCI-designated comprehensive cancer center based in the county. The mission and long-range goal of the CFCCC's Community Outreach and Engagement (COE) is to reduce cancer-related burdens in the Catchment Area through cancer monitoring, community outreach and education, leadership on county coalitions and statewide partnerships including the California Cancer Plan, policy advocacy, and facilitation of research that promotes cancer health equity within and beyond the Catchment Area. The Specific Aims of the COE component are: 1) to identify and characterize the cancer burden in OC; 2) to partner with community leaders and organizations for outreach education; and 3) to facilitate community engagement in research. COE is led by Associate Director for Cancer Health Disparities & Community Engagement Sora Park Tanjasiri, DrPH, MPH, a well-established cancer health disparities researcher with deep ties and relationships throughout OC. The Office of COE is composed of a masters-level Director and two community health educators who are supported by CFCCC funds under the authority of the Cancer Center Director. These staff engage in activities covering the continuum of community engagement, including principles of community-based participatory research, to establish and facilitate partnerships with community-based organizations, clinics, and public agencies. Guided by both the overall CFCCC strategic plan and a COE-specific strategic plan, COE works collaboratively with the Community Equity Board to identify cancer education needs and to deliver evidence- based outreach education to address social, behavioral, and environmental risks within and beyond the Catchment Area, including the California HPV Vaccination Roundtable and pivoting to address urgent COVID- 19 needs across Southern California. Since its inception, COE has strategically guided the design, implementation, and dissemination of research studies that refle...