ABSTRACT The goal of the Cold Spring Harbor Laboratory (CSHL) Postbaccalaureate Research Education Program (PREP) is to increase the number of underrepresented minority (URM) students in the biomedical sciences by preparing trainees for matriculation into highly competitive and rigorous Ph.D. graduate programs and future success in science-related fields. CSHL PREP will provide world-class research experience, professional development, and development of scientific identity and community to its participants. Funding is requested for four PREP Scholars to conduct a year of research in cancer and molecular biology, neuroscience, genetics and genomics, quantitative biology, and plant biology, under the mentorship of a CSHL PREP faculty member. Scholars will create an individual development plan that defines their research interests, identifies relevant coursework, and establishes goals and timelines for their time in the program and their future careers. They will participate in the Skills Development course, designed exclusively for them, that includes writing and oral presentation workshops, and guidance in preparing for graduate school applications. They will also attend the PREP Bootcamp course to broaden their knowledge base in the biosciences. Scholars will have numerous opportunities to develop their scientific identity and community. They will participate in campus-wide seminars, meetings and journal clubs with their research laboratories, national conferences, and the graduate student run Graduate Seminar Series. They will benefit from having a Research Mentor, a Direct Mentor (a graduate student or postdoc in their research laboratories) and a Near-Peer Mentor (a graduate student). These mentors will play an active role in integrating the Scholars into the CSHL community, and help them build a scientific network, such as with the approximately 12,000 scientists that visit CSHL annually to attend the Meetings and Courses program. The PREP Committee will have oversight of CSHL PREP. The committee will meet monthly with the Scholars at PREP Teas, and with the Scholar and their Research Mentor in quarterly Progress Meetings. Moreover, the Program Director and Program Coordinator will have Check-In meetings with individual Scholars monthly. Effectiveness of CSHL PREP will be evaluated internally by CSHL’s School administrators and externally by Barone Research Services through a combination of survey results, confidential reports by Research Mentors, and exit interviews.