# Refining the Genetic and Genomic Architecture of Non‐syndromic Orofacial Clefts

> **NIH NIH R01** · UNIVERSITY OF IOWA · 2022 · $627,383

## Abstract

PROJECT SUMMARY
The focus of this study is to identify meaningful genetic and genomic factors that predict cleft
outcomes in families in the African population, translate findings to other populations in order to
design strategies towards reducing the outcome and prevention of CLP. We plan to replicate
African GWAS significant loci in 1000 CL/P cases, 400 CP and 2000 controls by genotyping 172
single nucleotide polymorphisms. We also plan to conduct whole genome sequencing of 300
triads (proband with bilateral complete cleft lip and palate) and analyses whole genome
sequencing (WGS) data of 150 CL/P triads. Finally, we plan to determine the functional
consequences of GWAS non-coding variants by systematically testing SNPs with strongest
disease association. This study will be led by Dr Butali at the University of Iowa in collaboration
with Dr Cornell, Dr Murray and Dr Cao at the University of Iowa, Dr Adeyemo at the NHGRI and
Dr Taub at the John Hopkins University.

## Key facts

- **NIH application ID:** 10337034
- **Project number:** 5R01DE028300-03
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** Azeez Butali
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $627,383
- **Award type:** 5
- **Project period:** 2020-02-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10337034

## Citation

> US National Institutes of Health, RePORTER application 10337034, Refining the Genetic and Genomic Architecture of Non‐syndromic Orofacial Clefts (5R01DE028300-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10337034. Licensed CC0.

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