# Study of early brain alterations that predict development of chronic PTSD

> **NIH NIH R01** · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · 2021 · $293,686

## Abstract

Project Summary
Traumatic experience leads to development of posttraumatic stress disorder (PTSD) in some, but not all,
trauma survivors. The funded R01 grant is focused on identifying human brain emotion circuit changes within
early post-trauma weeks that predict subsequent PTSD versus non-PTSD diagnosis in the months-years after
trauma (Specific Aim 1). The grant further examines progressive changes in brain emotion circuits that
associate with PTSD symptom progression from weeks to a year after the trauma (Specific Aim 2). The
approved study design requires recruiting 283 traumatized patients from Emergency Departments (EDs) to
provide longitudinal sampling over a year in 144 subjects, about 35% (50 subjects) of which will likely develop
PTSD. Study recruiting and longitudinal retention progressed as planned over the initial 3.7 years until the
COVID-19 pandemic forestalled recruitment and reduced retention after March 2020 during year 4. Due to
federal, state, county, and University of Toledo mandatory guidelines, the research team has had to modify
protocols in attempts to maintain progress. Modified procedures include e.g., consent over the phone, online
surveys and virtual diagnostic interviews, disinfecting study areas frequently, and providing MRI compatible
personal protection equipment (PPE) to study personnel and subjects. Pandemic disruptions have also
required increased efforts in subject recruitment and retention. Procedural changes are gradually allowing us to
resume the study and have been effective in protecting subjects and researchers. However, this is at the price
of unavoidable, unanticipated slow-downs and costs. To complete the proposed sampling and final data
analyses, this requested Administrative Supplement will underwrite these unexpected costs and is critical for
completing the originally planned work.

## Key facts

- **NIH application ID:** 10337146
- **Project number:** 3R01MH110483-05S1
- **Recipient organization:** UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
- **Principal Investigator:** Xin Wang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $293,686
- **Award type:** 3
- **Project period:** 2021-04-28 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10337146

## Citation

> US National Institutes of Health, RePORTER application 10337146, Study of early brain alterations that predict development of chronic PTSD (3R01MH110483-05S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10337146. Licensed CC0.

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