# Stress-Chemical Interactions and Neurobehavior in School Age Children

> **NIH NIH R01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $42,261

## Abstract

PROJECT SUMMARY
Air pollution can impact cognitive disorders such as attention deficit hyperactivity and behavioral problems.
Children are particularly vulnerable to environmental exposures because of the sensitive nature of child
development, a life stage marked by rapid cell differentiation. A growing body of literature on air pollution shows
increasingly diverse effects on childhood health, development and disease. This research study will further add
to the literature by both addressing the main effect of air pollution on sleep and the modifying effect of co-
exposure to social stressors. Specifically, we will examine potential relationships between ambient air quality
and its effects on sleep patterns among children, 6-7 years old. Specific Aim are to: 1) Determine the association
of prenatal PM2.5 exposure and child sleep quantity and awakening at night assessed at 6-7 years using a satellite
remote sensing PM2.5 model and wrist-worn continuous actigraphy over 7 days; 2) Determine if early life stress
indexed by negative life events, maternal trauma, and exposure to violence predicts sleep quantity and
awakening at night and modifies the impact of prenatal PM2.5 on sleep assessed at age 6-7 years. By identifying
risk factors for poorer sleep phenotypes, we can begin to address interventions targeting toxic impacts on child
health. Furthermore, I posit that ambient air quality and sleep may work independently or synergistically through
a shared inflammatory pathway, and thus a better understanding of this relationship could mitigate modifiable
risk factors that improve childhood health outcomes. It is further postulated that this proposed research will
contribute to the sparse literature on air quality and sleep health among children by examining pediatric
environmental health, ambient air quality and potential stress induced modifying effects on sleep patterns in
children. Using the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS)
longitudinal birth cohort study to conduct the proposed research, this study will expand the literature on sleep
and sleep disparities, a research void that if addressed has the potential to mitigate the adverse impact of child
sleep disparities on long term health.

## Key facts

- **NIH application ID:** 10337782
- **Project number:** 3R01ES013744-14S1
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Robert O Wright
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $42,261
- **Award type:** 3
- **Project period:** 2021-05-28 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10337782

## Citation

> US National Institutes of Health, RePORTER application 10337782, Stress-Chemical Interactions and Neurobehavior in School Age Children (3R01ES013744-14S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10337782. Licensed CC0.

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