# PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns

> **NIH NIH R41** · BIOAESTHETICS CORPORATION · 2021 · $52,000

## Abstract

PROJECT SUMMARY
BioAesthetics is developing a novel acellular graft for improved burn wound healing. Our patent-
pending drug-loaded, polymer-integrated acellular biologic graft (PCT/US19/25306) will act as a
barrier to pathogens, deliver anti-infectives to the wound site during healing, and provide an
optimal regenerative scaffold. This will allow for a single-stage wound reconstruction, without the
need for additional patient-derived tissue, of full-thickness burns (e.g., second- and third-degree
burns). Our predicate STTR Phase 1 grant is geared towards providing proof-of-concept that our
grafts are capable of promoting wound healing and preventing infection in burn wounds in vivo.
The goal of this proposal is to enroll in the NIH I-corps program, which will help BioAesthetics
validate customer needs and commercialize this technology. Our objective within the NIH I-corps
program is to understand the larger ecosystem surrounding tissue graft use, including clinician
product preference in treatment of burns, pricing and reimbursement through hospitals and
insurer networks, and antimicrobial use. In the US, burns requiring medical treatment affect nearly
500,000 people each year, causing approximately 40,000 hospitalizations and 3,400 deaths. A
2010 Healthcare Cost and Utilization Project brief reported that approximately $1.5B was spent
in the US on burn-related injuries, with an additional $5B linked to lost work. Many clinical
challenges exist related to burn treatment including infection, time to wound closure, and time to
functional recovery, which can result in long hospital stays, high treatment costs, and an increased
risk of contracting a drug-resistant infection. There is a significant unmet need to identify novel,
innovative approaches to safely treat patients with serious burn wounds. We believe that our
enhanced acellular graft will be able to rapidly heal infected burn wounds, reduce the need for
antibiotics, not require additional surgeries, and improve patient quality of life.

## Key facts

- **NIH application ID:** 10338915
- **Project number:** 3R41GM140660-01S1
- **Recipient organization:** BIOAESTHETICS CORPORATION
- **Principal Investigator:** Nicholas Pashos
- **Activity code:** R41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $52,000
- **Award type:** 3
- **Project period:** 2021-01-18 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10338915

## Citation

> US National Institutes of Health, RePORTER application 10338915, PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns (3R41GM140660-01S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10338915. Licensed CC0.

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