# Core B

> **NIH NIH U19** · BETH ISRAEL DEACONESS MEDICAL CENTER · 2022 · $993,882

## Abstract

Core B (Immunology Core) will provide standardized humoral immune monitoring assay services for
evaluating antibody responses elicited by Ad26-Env/Gag/Pol prime, Env gp140 protein boost (Ad26/Env)
vaccine regimens in the studies described in this IPCAVD program. Core B leadership will work closely
with investigators responsible for the studies described in Project 1 and Project 2 and will participate actively in
the scientific mission of the overall IPCAVD program. The primary goal of Core B is to provide the leadership
and the technical expertise to ensure that all vaccine-induced humoral responses will be profiled in a
standardized fashion and that the IPCAVD leadership is kept abreast of the latest developments in assessing
vaccine-induced neutralizing and non-neutralizing humoral immunity, particularly in relation to their ability to
prevent viral infection. To accomplish these goals, we propose the following three Specific Aims:
Specific Aim 1. To perform standardized neutralizing antibody (NAb) assays in both NHP and humans
Specific Aim 2. To perform standardized non-neutralizing antibody assays in both NHP and humans
Specific Aim 3. To integrate all antibody data into a Systems Serology profiling approach to define correlates
of protective immunity

## Key facts

- **NIH application ID:** 10339364
- **Project number:** 5U19AI128751-05
- **Recipient organization:** BETH ISRAEL DEACONESS MEDICAL CENTER
- **Principal Investigator:** Galit Alter
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $993,882
- **Award type:** 5
- **Project period:** 2018-02-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10339364

## Citation

> US National Institutes of Health, RePORTER application 10339364, Core B (5U19AI128751-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10339364. Licensed CC0.

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