# Transcriptional regulation of T cell immunity

> **NIH VA I01** · VA SAN DIEGO HEALTHCARE SYSTEM · 2022 · —

## Abstract

Summary
Infectious diseases, including Hepatitis C (HCV) and HIV, remain important health problems among Veterans.
Development of vaccines for infectious diseases is therefore a key priority. Immunologic memory is a cardinal
feature of adaptive immunity and an important goal of vaccination strategies. Traditional vaccination strategies
are very effective at generating neutralizing antibodies, but not effective T cell memory. A key reason for the
current lack of effective vaccines against many infectious diseases is that we do not yet know how to make
vaccines that generate robust T cell memory. Thus, a fundamental understanding of how memory cells are
formed is a crucial first step in rational vaccine design for infectious diseases.

## Key facts

- **NIH application ID:** 10341041
- **Project number:** 5I01BX005106-02
- **Recipient organization:** VA SAN DIEGO HEALTHCARE SYSTEM
- **Principal Investigator:** John T Chang
- **Activity code:** I01 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2022
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2021-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10341041

## Citation

> US National Institutes of Health, RePORTER application 10341041, Transcriptional regulation of T cell immunity (5I01BX005106-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10341041. Licensed CC0.

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