# CCR7 Chemotaxis Regulates Memory T Cell Localization

> **NIH NIH SC1** · UNIVERSITY OF TEXAS EL PASO · 2022 · $377,500

## Abstract

ABSTRACT When humans are exposed to a substance that causes an immune response, to protect the itself,
the body generates antibodies. There is very little understood about the role of chemokines in regulating the
extent of the immune response, as measured by antibody titers and types of antibodies that are made. We
have found that C-C chemokine receptor 7 regulates the antibody titers by controlling the localization of
different populations of immune cells to the bone marrow. In this proposal our goal is to better understand the
molecular mechanisms that are employed by immune T cells to respond to C-C chemokine receptor 7
activation that regulate the targeting of T cells to the bone marrow where they regulate the isotype switching
and antibody production by immune cells. Our study is important since these antibodies protect the host when
he or she is exposed to the same substance during a secondary immune response. We hypothesize that
CCR7 regulates the migration of memory T, and regulatory T cells to the bone marrow to limit the activation of
B cells during an adaptive immune response. With the knowledge we gain we will determine if redirection of
the T cells can be applied to inhibit excessive immune responses observed during autoimmune diseases.

## Key facts

- **NIH application ID:** 10341145
- **Project number:** 5SC1GM111172-07
- **Recipient organization:** UNIVERSITY OF TEXAS EL PASO
- **Principal Investigator:** Charlotte M Vines
- **Activity code:** SC1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $377,500
- **Award type:** 5
- **Project period:** 2015-07-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10341145

## Citation

> US National Institutes of Health, RePORTER application 10341145, CCR7 Chemotaxis Regulates Memory T Cell Localization (5SC1GM111172-07). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10341145. Licensed CC0.

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