# Trans-America Consortium of the Health Care Systems Research Network for the All of Us Research Program

> **NIH NIH OT2** · HENRY FORD HEALTH SYSTEM · 2021 · $11,764,077

## Abstract

Clinicians throughout history have worked to tailor both prevention and treatment strategies
to the individual patient’s needs; it is a fundamental credo to the practice of medicine. However, the vast
majority of evidence-based clinical practice is based on research results acquired from measuring the
common treatment effect on the “average person” in a restricted patient population with limited data, which
we now know does not necessarily apply to numerous patients in the real-world setting. Thus, some patients
will benefit from evidence-based treatments and preventative interventions, while others will be harmed by
taking medications or undergoing processes and procedures that are at best non-effective and at worst
cause serious side effects. However, since the initiation of pharmacogenomics in the mid-90s, the
astounding pace of development of the technical and analytic tools to measure individual inherited and
acquired biological variations at all physiological levels, as well as efficiently capture a patient’s medical and
risk factor history and personal preferences via electronic means, is at a scale never before known.(PMIDs:
26554403, 26804248,26802434,26686739, 26769233, 26702339, 26700443, 26764593, 25231862) The
current concept of “Personalized Medicine” or “Precision Medicine” in which these tools can be deployed to
sharply hone predictions about an individual’s risk for disease or response to treatment, while still in its
infancy, has immeasurable potential.(PMIDs:20551152,26014593,26810587) Further, the costs for next
generation sequencing are expected to continue to decline as technology advances. (PMIDs: 24217348,
26195686) As resources are becoming increasingly constrained, it is important to devote scientific time,
energy and dollars to questions that matter to the community and have strong potential for effectively
improving medical care, public health and wellness. Hence the need, creation, and continuing development
of the All of Us Research Program (AoURP). (http://www.pmwcintl.com/francis-collins-nih-qa/)
The promise of Precision Medicine in the U.S. can be most effectively realized on a large scale in the next
decades if a research infrastructure is established and accessible to scientists across the nation and includes a
large and engaged study population with comprehensive health and lifestyle histories linked to biospecimens.
Critically, this population must be diverse, representing minority and other subgroups underrepresented in
biomedical research. (PMID:23571593) Further, as our investigators and others have recently published, the
need to engage all stakeholders, including patients and providers, into both the research and “integration into
practice” aspects of Precision Medicine as it progresses, is widely recognized. (PMID:27787499, 27669484,
20805700, 22962560,23780455, 24030437,26195686) Our Consortium objective is to recruit 93,000
participant partners into the AoURP, with a focus on African Americans, Arab Am...

## Key facts

- **NIH application ID:** 10344115
- **Project number:** 3OT2OD026550-01S3
- **Recipient organization:** HENRY FORD HEALTH SYSTEM
- **Principal Investigator:** Brian Kenneth Ahmedani
- **Activity code:** OT2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $11,764,077
- **Award type:** 3
- **Project period:** 2018-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10344115

## Citation

> US National Institutes of Health, RePORTER application 10344115, Trans-America Consortium of the Health Care Systems Research Network for the All of Us Research Program (3OT2OD026550-01S3). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10344115. Licensed CC0.

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