# Core B:  System Biological Analyses of Innate and Adpative Responses to Vaccination

> **NIH NIH U19** · EMORY UNIVERSITY · 2021 · $466,445

## Abstract

Abstract 
The Clinical Core serves to support the two research projects of the U19 research 
program. The Clinical Core will provide the research projects with appropriate human 
clinical specimens and data from different studies to better understand adaptive and 
innate immunity to vaccination for Streptococcus pneumoniae and varicella zoster virus. 
The specific aims of the Clinical Core are: 
Specific aim 1) To provide clinical study expertise and capacity to ensure the 
success of the U19 scientific agenda. The support activities to be provided include: 
study design; clinical protocol and informed consent form preparation; obtaining required 
regulatory approvals; designing case report forms and the clinical database; outreach 
and education with communities in which recruiting will occur; recruitment, screening, 
and enrollment; clinical study conduct according to Good Clinical Practice (GCP) 
standards; establish a system of records, including source data and essential 
documents; subject safety monitoring; clinical specimen collection, processing, tracking, 
storage, and shipping; preparation of progress reports, final report, presentations, and 
publications. 
Specific aim 2) To perform clinical studies with varicella vaccine, zoster vaccine, 
and pneumococcal vaccines in different populations (children, adults, elderly and 
immunocompromised) that will provide the clinical specimens and data necessary 
to accomplish the scientific aims of the related research projects. 
Specific aim 3) To perform assays for endpoint immune responses that will 
provide read out for varicella zoster virus (VZV) serology and blood count assays.

## Key facts

- **NIH application ID:** 10345983
- **Project number:** 3U19AI090023-11S2
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Mark Joseph Mulligan
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $466,445
- **Award type:** 3
- **Project period:** 2021-03-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10345983

## Citation

> US National Institutes of Health, RePORTER application 10345983, Core B:  System Biological Analyses of Innate and Adpative Responses to Vaccination (3U19AI090023-11S2). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10345983. Licensed CC0.

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