# Opioid Policy Model

> **NIH NIH R01** · RESEARCH TRIANGLE INSTITUTE · 2022 · $630,941

## Abstract

PROJECT SUMMARY/ABSTRACT
 In this study we will develop an agent-based simulation model (ABM) to help policy makers and health
professionals in North Carolina identify the best mix of cost-effective interventions to reduce opioid
overdoses (ODs) and related deaths. Interventions are identified in the NC Opioid Action Plan and cover
the Three Pillars: prevention, connection to care, and harm reduction.
 Our ABM will represent a community (e.g., a town) of individuals (patients, physicians, dealers, etc.), and
simulate how proposed interventions affect individual pathways to opioid misuse and other outcomes (i.e.,
OD death). The estimation of transition probabilities between the states in these pathways will be based on
data from several sources: North Carolina dashboard, national studies, and published literature. The model
will rely on a representative synthetic population, which allows multiple data types (e.g. prevention,
treatment) to be probabilistically connected in one model.
Aim 1. To develop a North Carolina-specific ABM that describes multiple pathways of opioid use in the
context of prescription practices, treatment modality and availability, the illegal drug market, prevention
policies, and other factors affecting the parameters of the various pathways that lead to OD fatalities.
Besides OD deaths, we will investigate multiple other sources of morbidity. We will leverage existing
national models and a representative synthetic population to examine spatial (community-level) and
temporal (short- and long-term) effects of prevention and treatment interventions on opioid misuse and
ODs. We will validate the model on North Carolina data from the past 13 years and will evaluate the
sources of prediction uncertainty.
Aim 2. To predict the response to the mix of interventions specified in the North Carolina Opioid Action
Plan at the local level (e.g., county). The policies include reducing the over prescription of POs, increasing
naloxone availability, increasing community awareness, and expanding treatment and recovery care. We
will estimate the uncertainty of the forecasts accounting for the changing policy and environmental factors
and will refine the model on the basis of new data from the NC DHHS. We will discuss the results with the
expert panel and will disseminate data-driven recommendations to North Carolina stakeholders to generate
public health impact.
Aim 3. To estimate the cost and cost-effectiveness of the key interventions in Aim 2 and compare them
with the status quo. For each intervention, we will work with the NC DHHS to estimate costs and cost
variation by county characteristics (e.g., population density, poverty). The model will address a significant
public health problem and will inform policy on the short- and long-term cost-effectiveness of these
interventions.

## Key facts

- **NIH application ID:** 10347344
- **Project number:** 5R01DA047994-03
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** GEORGIY BOBASHEV
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $630,941
- **Award type:** 5
- **Project period:** 2020-04-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10347344

## Citation

> US National Institutes of Health, RePORTER application 10347344, Opioid Policy Model (5R01DA047994-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10347344. Licensed CC0.

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