# Functional Microbiomics Core-Bodduluri

> **NIH NIH P20** · UNIVERSITY OF LOUISVILLE · 2022 · $547,117

## Abstract

Biomedical research areas including the study of metagenomics, inflammation and pathogenesis are resource 
and technology intense. All COBRE-supported investigators require state of-the-art resources to successfully 
compete with investigators from other resource-rich institutions for NIH support. The primary goal of the 
Functional Microbiomics Core (FMC) is to establish an integrated service center that functions as a critical 
resource for all Microbiome, Inflammation and Pathogenicity COBRE investigators. Since all the COBRE projects 
utilize mouse models to explore the inter-relationships between inflammation and pathogenesis, and the 
contribution of microbiota to this process, the development of a facility to house and maintain germ-free and 
gnotobiotic mice is crucial to the FMC. An anaerobic culture facility will support research on gnotobiotic mice that 
requires specific colonization with fecal transplants or defined anaerobic bacteria. Further, in Aim 2, we propose 
to establish an integrated metagenomics center for microbiota. This facility will prepare genomic DNA following 
unified protocols and generate 16S rRNA gene amplicon sequences, and provide bioinformatics support for all 
microbiota analysis. The FMC will also support all COBRE projects with analysis of their biological samples for 
inflammatory markers as well as histopathological examination of tissue sections. Education and training of junior 
investigators and the university wide research community in microbiota research is an important goal of the FMC. 
Towards this goal, the FMC will organize seminars as well as informal meetings that will serve as a forum for 
highlighting the scientific and technical advances in the field. Finally, the FMC plans to become an independent 
service center at UofL to support the needs of all researchers in this area of research

## Key facts

- **NIH application ID:** 10349568
- **Project number:** 5P20GM125504-05
- **Recipient organization:** UNIVERSITY OF LOUISVILLE
- **Principal Investigator:** HARIBABU BODDULURI
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $547,117
- **Award type:** 5
- **Project period:** 2018-03-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10349568

## Citation

> US National Institutes of Health, RePORTER application 10349568, Functional Microbiomics Core-Bodduluri (5P20GM125504-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10349568. Licensed CC0.

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