# Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2021 · $109,879

## Abstract

Project Summary/Abstract
This request for an administrative supplement to promote diversity will allow Dr. Shauna Otto
(PhD expected March, 2021) to train as a postdoctoral scholar in the Gordon lab. She will work
on subaims 1b and 2a of the parent grant. These aims address the molecular mechanisms by
which the inflammatory factor Nerve Growth Factor regulate sensitization to painful stimuli in
pain receptor neurons. This is an especially important system to understand in the cornea,
where suppression of Nerve Growth Factor signaling has been shown to both relieve pain and
interfere with healing during injury/inflammation. Dr. Otto’s will train directly under Dr. Gordon in
the experimental methods required: single-molecule assays for phosphoinositide 3-kinase
(PI3K) activity using supported lipid bilayers. Using this system, Dr. Otto will study the
interactions between the ARD region of TRPV1, the pain-transducing ion channel, and PI3K

## Key facts

- **NIH application ID:** 10350372
- **Project number:** 3R01EY017564-13S1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Sharona E Gordon
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $109,879
- **Award type:** 3
- **Project period:** 2006-09-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10350372

## Citation

> US National Institutes of Health, RePORTER application 10350372, Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea (3R01EY017564-13S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10350372. Licensed CC0.

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