# Core A: Administrative Core

> **NIH NIH P42** · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2022 · $194,481

## Abstract

PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE
N-nitrosamines are a family of chemicals that include some of the most potent mutagens known. N-nitrosamines
are a major concern for people who live near the Olin Chemical Superfund Site, which is contaminated with
millions of gallons of waste containing high levels of N-nitrosodimethylamine (NDMA), a probable human
carcinogen. NDMA is also a concern of the Passamaquoddy Tribe, because the water treatment methods used
for their drinking water are known to lead to formation of NDMA. The mission of the Administrative Core is to
enable a Systems Approach wherein impact on public health is made possible via a network of interactions and
interdependencies among Projects, Cores, and stakeholders. The resulting ‘MIT SRP Interactome’ results from
research meetings, enrichment activities, workshops, retreats, poster sessions, trainee collaboration meetings,
and meetings with stakeholders. Team building will be further strengthened via adoption and enhancement of
team science values. Translation will be fostered via support of Project and Core leaders in developing and
executing their Investigator Initiated Research Translation plans and by continual input and suggestions from
the Administrative Core leadership, and in particular the Research Translation Coordinator. In addition to its
Systems Approach, other innovative goals include facilitation of bidirectional communication with the National
Toxicology Program to enable the MIT team to cater technologies to meet the needs for high-throughput screens
for chemical safety and working with the Community Engagement Core (CEC) to deploy N-nitrosamine sensors
and remediation devices that destroy N-nitrosamines. Specific Aim 1 is to lead and coordinate in order to
achieve a robust programmatic ‘MIT SRP Interactome’ that will give rise to results and deliverables that
contribute to the protection of human health from hazardous substances. Specific Aim 2 is to partner
and promote by translating knowledge and technologies to local, state, national, and tribal
organizations. Specific Aim 3 is to achieve a broader impact via dissemination of knowledge and by
building a better future for the next generation of leaders in environmental health sciences.
Communication and data sharing will be further strengthened by the Data Management and Analysis Core
(DMAC), which will deliver computational methods for integrating data streams from across disciplines in order
to contribute to a better understanding of risk, improved ability to predict disease, and new opportunities for
interventions. The Administrative Core will also work closely with the Research Experience and Training
Coordination Core (RETCC) to coordinate training and support for trainees. Taken together, the Administrative
Core is the cog that drives the program forward by creating tight collaborations and interdependencies within the
MIT SRP and with its local, state and national stakeholders, that together enable...

## Key facts

- **NIH application ID:** 10351936
- **Project number:** 2P42ES027707-06
- **Recipient organization:** MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** Bevin P. Engelward
- **Activity code:** P42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $194,481
- **Award type:** 2
- **Project period:** 2017-09-01 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10351936

## Citation

> US National Institutes of Health, RePORTER application 10351936, Core A: Administrative Core (2P42ES027707-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10351936. Licensed CC0.

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