# REMISE study: REMnant biospecimen Investigation in SEpsis

> **NIH NIH R21** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $225,960

## Abstract

PROJECT SUMMARY / ABSTRACT
Almost 2 million Americans are hospitalized with sepsis each year, and nearly one in five
don’t survive. Most efforts to reduce sepsis deaths begin with the premise that patients
are largely similar, and that targeting therapeutics to a single mechanism will improve
outcomes. But sepsis patients differ in pathogen, biology, outcomes, and are proposed
to have treatment responsive endotypes. Greater study of sepsis endotypes has been
limited by costly infrastructure and biospecimen collection that is not scalable. To solve
this challenge, we will use a clinical remnant biorepository to understand feasibility,
integrity, and scientific value for mechanistic sepsis research. We will evaluate traditional
biomarkers, quantitative proteomics, metabolomics, lipidomics, and pathogen genomic
sequencing in remnant specimens and graduate successful data “layers” to a scaled,
community hospital repository. This cross-cutting project will be supervised by an
external advisory board with expertise in inflammation, immunology, computational and
systems biology, and laboratory and pathology medicine. This approach will further
develop our NIGMS-funded clinical-translational laboratory, creating new hypotheses
from a diverse, academic and community hospital remnant biorepository acquired from
an endotype-enriched population of sepsis patients. Finally, we will further integrate
these data with multi-omics read-outs in severely injured trauma patients to explore
shared/unshared mechanisms in critical illness.

## Key facts

- **NIH application ID:** 10352753
- **Project number:** 1R21GM144851-01
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Christopher Warren Seymour
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $225,960
- **Award type:** 1
- **Project period:** 2022-01-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10352753

## Citation

> US National Institutes of Health, RePORTER application 10352753, REMISE study: REMnant biospecimen Investigation in SEpsis (1R21GM144851-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10352753. Licensed CC0.

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