# HEAL Diversity Supplement: Great Lakes Nodes Clinical Trials Network

> **NIH NIH UG1** · RUSH UNIVERSITY MEDICAL CENTER · 2021 · $70,982

## Abstract

Project Summary/Abstract
We assess the feasibility of mobile technologies to study the psychophysiological underpinnings
of affect in Opioid Use Disorder (OUD). In this feasibility pilot study, we will evaluate
participants’ adherence to the procedures of a longitudinal study, including: 1. wearing wearable
sensors for the duration of the study, 2. completing research activities involving prompted and
self-initiated self-reports on momentary experiences of stress and negative affect. We will also
examine the validity and reliability of the physiological data captured with two wearable sensors
from two different brands and that are placed in different body locations. It is important to
assess the reliability of data from two devices simultaneously to examine issues that may hinder
a study’s viability, like data noise, signal problems, or data loss, etc. Lastly, we will utilize this
data to investigate the role of autonomic function as a valid physiological marker of stress and
negative affect in OUD. This has relevant implications in the understanding and development of
digital treatments, as stress and negative affect are major contributors of relapse. This pilot work
will contribute to the aim 2 of the parent grant by using digital and computational health cores to
advance research in mHealth, artificial intelligence, and machine learning. In addition, the work
supported under this supplement will serve as a building block to successfully create and submit
an F31 grant proposal, a research that will be carried out following the diversity supplement
period. This supplement will support the intensive training and invaluable practical experience
that will advance the career of the trainee, Veronica Ramirez. This is in alignment with aim 6 of
the parent grant to “expand the pipeline for early investigators” and create programs that
support “addiction and substance misuse research, training, and mentorship”. Aligned with this,
our research can ultimately help current efforts to address the opioid epidemic to ameliorate its
detrimental effects on society.

## Key facts

- **NIH application ID:** 10354615
- **Project number:** 3UG1DA049467-03S2
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Niranjan Subhash Karnik
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $70,982
- **Award type:** 3
- **Project period:** 2019-06-15 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10354615

## Citation

> US National Institutes of Health, RePORTER application 10354615, HEAL Diversity Supplement: Great Lakes Nodes Clinical Trials Network (3UG1DA049467-03S2). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10354615. Licensed CC0.

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