# Developing and Testing a Multi-level Package of Interventions for an Integrated Care Delivery Model of HIV Prevention and Treatment in Zambia: Targeting Adolescent  Boys and Young Men

> **NIH NIH UH3** · RESEARCH TRIANGLE INSTITUTE · 2021 · $32,121

## Abstract

PROJECT SUMMARY/ABSTRACT
Zambia has one of the highest incidences of HIV in the world. Adolescent girls and young women (AGYW)
are a particularly affected group because of their social and economic vulnerability. There is growing
recognition of the importance of including adolescent boys and young men (ABYM) in HIV prevention
research. During adolescence and early adulthood, boys have significantly lower HIV prevalence than
AGYW. However, adolescent boys experience large increases in HIV prevalence in the years that follow,
which thereby indicates that adolescence may be a critical time when boys should be engaged in HIV
prevention.
With this administrative supplement, we propose to add a cohort of ABYM to explore the efficacy of tailored
multilevel interventions on HIV outcomes. The overall goal of the supplement is to assess gender differences
related to both efficacy and implementation outcomes of the multicomponent interventions. We will develop
tailored education materials targeted at ABYM to complement the SHIELD (Support for HIV Integrated
Education, Linkages to care, and Destigmatization) education modules developed for AGYW. We will
conduct similar interventions for ABYM as planned for AGYW in the community setting and support linkages
to the Integrated Wellness Care (IWC) clinics already established for the parent study. We will select 300
ABYM from the previously enrolled cohort for inclusion in the study. As stated in the parent grant, we will
compare (1) the SHIELD community intervention only, (2) SHIELD and clinic-based interventions, and (3) the
standard of care. We will pursue the following specific aims in this administrative supplement: Aim 1 is to
include ABYM in assessing efficacy at 6 and 12 months of the multilevel interventions at the individual (HIV
knowledge, self-efficacy), interpersonal (social support, stigma reduction), and health system (clinic-based
multiple services) levels on HIV testing, retention in care, and viral load suppression using a cluster
randomized design and Aim 2 is to assess implementation outcomes and cost-effectiveness of the
interventions targeted at ABYM to support scale-up and sustainability.
Including a cohort of ABYM will enhance the study by supplementing the data gathered from the cohort of
AGYW to understand the impact of gender equality and norms on outcomes along the HIV continuum of
care. The findings from the supplement and parent grant will allow us to design a comprehensive program
for adolescents that can be implemented in the community setting along with sustainable linkages to the
existing health care delivery system.

## Key facts

- **NIH application ID:** 10355670
- **Project number:** 3UH3HD096908-03S1
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** SUJHA SUBRAMANIAN
- **Activity code:** UH3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $32,121
- **Award type:** 3
- **Project period:** 2021-05-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10355670

## Citation

> US National Institutes of Health, RePORTER application 10355670, Developing and Testing a Multi-level Package of Interventions for an Integrated Care Delivery Model of HIV Prevention and Treatment in Zambia: Targeting Adolescent  Boys and Young Men (3UH3HD096908-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10355670. Licensed CC0.

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