The Einstein-Montefiore Institute for Clinical and Translational Research (ICTR) has developed and supported a highly integrated core of education and career development programs in clinical and translational research. In this new application, we describe our KL2 program, along with a range of synergistic and complementary career development award (CDA) programs. Along with a menu of didactic offerings, led by our flagship educational program, the MSc-granting Clinical Research Training Program (CRTP), these programs comprise a robust set of options to support the development of early-stage investigators. Our career development programs seek to accomplish the overarching goal: to identify, educate, support, and mentor talented clinical and non-clinical faculty and staff toward their development as impactful and successful clinical/translational scientists through working toward the following aims: 1) to build upon a robust foundation in clinical and translational research educational programs by developing new innovative programmatic initiatives, including methodologically-focused ‘tracks’ within our CRTP and novel applications of distance- and hybrid-learning technologies; 2) to promote team science competencies in our learners, while incentivizing and rewarding team science contributions in our institutional setting; 3) to effectively link research and health improvement through novel approaches to education and career development within a learning healthcare system, harmonizing scholarship and implementation and providing sustainable career pathways for clinician-investigators in research/healthcare teams; 4) to promote and support diversity in the clinical/translational research workforce. Our CTSA-funded CDA (KL2) program is coordinated with institutional and other, non-overlapping, extramural support, providing both leveraging and flexibility to maximize the impact of our efforts. KL2 Scholars are selected through a competitive study-section-type review process from among junior faculty at the Instructor or Assistant Professor level with sufficient background and experience to demonstrate their potential for a career in clinical or translational research. Each Scholar has an individually-tailored career development plan that is overseen by the Program Director, Dr. Paul Marantz. A special requirement of the program is that each applicant identify two mentors with appropriate and complementary experience and expertise, who also cross a “translational divide”. This new application builds on a 15-year track record of multidisciplinary career development efforts at Einstein-Montefiore, beginning in 2002 with an NCRR-funded K12 program. There have been 37 awardees over that time period, excluding the current Scholars. All 37 K Awardees have published since they received the KL2 grant. 95% have at least one first authored publication and 84% have been a senior author on at least one publication. 24 of the 37 awardees have gone on to obtain additi...