# Core C: Immune bioinformatics and biostatistics

> **NIH NIH P01** · UNIVERSITY OF PENNSYLVANIA · 2022 · $288,059

## Abstract

SUMMARY
The Immune Bioinformatics and Biostatistics (Core C) will provide critical infrastructure and shared resources
of biostatistic and bioinformatic expertise for the design, conduct and analyses of the Research Projects within
the P01 - “Radiation and Checkpoint Blockade for Cancer Immune Therapy.” Core C will provide services to
P01 projects at every stage of research. Core members will: 1) consult with investigators on selection of study
designs; 2) develop a relational database to store clinical trial patient correlative data for analysis; 3) generate
DNA and RNA-based massively parallel sequencing data from tumors, exosomes, PMBCs (T cells), and tumor
infiltrating lymphocytes; 4) conduct efficient and robust data analyses, utilizing both bioinformatics and
biostatistics; 5) perform higher level secondary and integrative analyses using multiple pre-clinical and clinical
data types; 6) create graphs and tables, assist investigators with the preparation of progress reports,
presentations and manuscripts; 7) consult on the design of subsequent research; and 8) be responsible for the
implementation of the Shared Resources Plan in regards to Genomic Data Sharing. These goals will be
implemented through the following specific aims – Aim 1) To provide biostatistical expertise in design and
analysis for the proposed projects; Aim 2) To provide support for the generation and initial analysis of DNA-
and RNA-based massively parallel sequencing data; and Aim 3) To perform secondary and integrative
analyses across platforms and data types. A major theme of the P01 is studying the effect of checkpoint
blockade and radiation therapy in humans through clinical trials, and concurrently performing linked pre-clinical
studies in mice. Core C members will play a vital role in facilitating the comparison between the two groups, as
they will be involved in the same analyses on human and mouse samples providing a conduit of knowledge
between Projects. Core members have extensive experience in clinical trials biostatistics, database design
and implementation, performance of massively parallel sequencing, bioinformatics analysis, and the utilization
of analytical techniques for integration of the multiple data types generated from the Projects. The Immune
Bioinformatics and Biostatistics Core will serve as an essential resource for the P01, providing specialized
expertise to allow investigators to complete their research in a robust and efficient fashion. Members of Core
C will work in a synergistic and cooperative fashion with Project investigators to determine the safety, efficacy
and mechanism of the combination of local radiation therapy and immune checkpoint blockade and to
understand the immunologic and genetic features of pre-clinical and clinical samples that are determinants of
response, resistance, and relapse.

## Key facts

- **NIH application ID:** 10360422
- **Project number:** 5P01CA210944-05
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Katherine L. Nathanson
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $288,059
- **Award type:** 5
- **Project period:** 2017-08-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10360422

## Citation

> US National Institutes of Health, RePORTER application 10360422, Core C: Immune bioinformatics and biostatistics (5P01CA210944-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10360422. Licensed CC0.

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