# Pre-metastatic Omental Niche Formation in Ovarian Cancer

> **NIH NIH R01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2022 · $353,518

## Abstract

Bowel obstruction is a leading cause of death in women with ovarian cancer and often stems from growth of
tumors on the omentum, a fat pad that suspends from the stomach. The objective of this project is to determine
the mechanisms that cause ovarian cancer cells to implant on the omentum, with the overarching goal of
identifying more effective therapies for this lethal disease. Previous studies of ovarian cancer metastasis have
mostly focused on investigating interactions of cancer cells with adipocytes, macrophages, fibroblasts and
mesothelial cells. However, as these stromal cells are constituents of all visceral fat pads, interactions with
these cells may not fully explain the tropism of ovarian cancer cells for the omentum. Neutrophils act as the
first line of defense in response to infection or malignancy. Because the omentum is the major site of neutrophil
influx into the peritoneal cavity, we speculate that neutrophils direct ovarian cancer cells to the omental niche.
This study focuses on a phenomenon in which neutrophils extrude sticky DNA webs called neutrophil
extracellular traps (NETs). NETs were originally discovered to trap microbes in infectious diseases but very
little is known about the significance of NETs in cancer. Based on our preliminary studies, we hypothesize that
ovarian cancer cells induce neutrophils to form NETs in the omentum, and that omental metastasis stems in
part from entrapment of cancer cells by NETs in the omental niche. In this project, we will determine whether
(1) ovarian cancers induce NET formation in the pre-metastatic omental niche, (2) omental metastasis of
ovarian cancer depends on NET formation and (3) omental metastasis is decreased by treatment with agents
that inhibit NETs. These aims will be accomplished by evaluating patient clinical specimens, mouse tumor
models and genetically modified mice that are defective in NET formation. Our study will provide new and
provocative insights into the mechanisms that drive the propensity of ovarian cancer to colonize the omentum
and the potential of repurposing NET-inhibiting agents for ovarian cancer therapy.

## Key facts

- **NIH application ID:** 10360586
- **Project number:** 5R01CA217931-05
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Honami Naora
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $353,518
- **Award type:** 5
- **Project period:** 2018-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10360586

## Citation

> US National Institutes of Health, RePORTER application 10360586, Pre-metastatic Omental Niche Formation in Ovarian Cancer (5R01CA217931-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10360586. Licensed CC0.

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