# Bioinformatics Shared Resource

> **NIH NIH P30** · WISTAR INSTITUTE · 2022 · $263,054

## Abstract

PROJECT SUMMARY – BIOINFORMATICS SHARED RESOURCE 
The Bioinformatics Shared Resource (BSR) provides Cancer Center (CC) members with access to state-of- 
the-art technology for analysis of high dimensional datasets involving next-generation sequencing, microarray, 
proteome and metabolome platforms, as well as integration of multi-omics results. The BSR develops 
algorithms, computational tools and databases ideally suited for the quantitative analysis of a wide variety of 
experimental questions in cancer research. Services offered by the BSR include: (i) statistical analyses and 
computational modeling; (ii) development of advanced bioinformatics tools for integrative cancer biology; and 
(iii) data management. The BSR has undergone significant growth in expertise and capabilities during the last 
Cancer Center Support Grant (CCSG) budget cycle. This was in response to the large thematic faculty 
recruitment in the CC, the expansion of computational-intensive research themes (cancer metabolism, 
phenotype profiling) and the growing need for high-dimensional data analysis across multiple technologies. 
Rehman Qureshi, Ph.D., Harsh Dweep, Ph.D. and Hideki Tanizawa, Ph.D. were recruited to the BSR staff 
during the last CCSG budget cycle to expand computational expertise; Wen-Hwai Horng, M.S. led the 
synergistic integration of system administration with a reorganized Wistar Information Technology (IT) 
Department, and a data analysis pipeline was developed synergistically with the Genomics, Proteomics and 
Molecular Screening Shared Resources to ensure seamless flow of data and appropriate quality control, 
feedback and troubleshooting. BSR staff and the Scientific Director are located within dry laboratory space in 
the Center for Systems and Computational Biology, next to Biostatistics faculty and post-doctoral fellows with 
strong interests in computational biology. The central location of the BSR facilitates scientific exchange and 
collaborations, thereby increasing the overall level of analytic approaches and quality of results. During the last 
CCSG budget cycle, CC members from all three Programs have extensively utilized BSR services contributing 
to a broad portfolio of cancer-related publications and grant awards. As an additional measure of the critical 
impact of its services, the BSR engages in productive collaborations with neighboring academic Institutions 
and Cancer Centers including the University of Pennsylvania, Children’s Hospital of Philadelphia (CHOP), Fox 
Chase Cancer Center, Lankenau Institute for Medical Research, and Drexel University. The expansion and 
refinement of bioinformatics tools of the last CCSG budget cycle have ideally positioned the BSR for state-of- 
the-art management of complex datasets and emerging technologies in sync with the recent CC expansion.

## Key facts

- **NIH application ID:** 10360636
- **Project number:** 5P30CA010815-53
- **Recipient organization:** WISTAR INSTITUTE
- **Principal Investigator:** Andrew V Kossenkov
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $263,054
- **Award type:** 5
- **Project period:** 1997-04-01 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10360636

## Citation

> US National Institutes of Health, RePORTER application 10360636, Bioinformatics Shared Resource (5P30CA010815-53). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10360636. Licensed CC0.

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